N,N-Dimethyl-idarubicin-trisaccharide

• UNSPSC Description:

  N,N-Dimethyl-idarubicin-trisaccharide (compound 26) is an efficient intercalating agent. N,N-Dimethyl-idarubicin-trisaccharide shows excellent cytotoxicity against ABCG2-overexpressing and ABCB1-overexpressing cells with IC50s of 19 and 32 nM, respectively[1].

• Target Antigen:

  Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/n-n-dimethyl-idarubicin-trisaccharide.html

• Smiles:

  O=C1C2=C(O)C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@H]5CCC([C@H](C)O5)=O)[C@H](C)O4)[C@H](C)O3)C[C@](O)(C(C)=O)C6)=C6C(O)=C2C(C7=C1C=CC=C7)=O

• Molecular Weight:

  767.82

• References & Citations:

  [1]van Gelder M A, et al. Novel N, N-Dimethyl-idarubicin Analogues Are Effective Cytotoxic Agents for ABCB1-Overexpressing, Doxorubicin-Resistant Cells[J]. Journal of Medicinal Chemistry, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3033865-28-7