TPI-1

• Description:

  TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phosphatase; SHP1

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/TPI-1.html

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  ClC1=CC (C2=CC (C=CC2=O) =O) =C (Cl) C=C1

• Molecular Formula:

  C12H6Cl2O2

• Molecular Weight:

  253.08

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184 (11) :6529-36.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  79756-69-7