TPI-1

• Description :

  TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Phosphatase; SHP1

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/TPI-1.html

• Purity :

  98.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC(C2=CC(C=CC2=O)=O)=C(Cl)C=C1

• Molecular Formula :

  C12H6Cl2O2

• Molecular Weight :

  253.08

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184 (11) :6529-36.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [79756-69-7]