Thalidomide-O-amido-C3-PEG3-C1-NH2

Thalidomide-O-amido-C3-PEG3-C1-NH2

• CAS Number: 1799711-29-7
• UNSPSC Description: Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-o-amido-c3-peg3-c1-nh2.html
• Purity: 99.08
• Solubility: DMSO : 200 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
• Smiles: O=C(NCCCOCCOCCOCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
• Molecular Weight: 648.58
• References & Citations: [1]Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016;26(21):5260-5262. doi:10.1016/j.bmcl.2016.09.048
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported