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PVRL4 Antibody / Nectin-4

CAT: 0800-V4056SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4056SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4) . The ectodomain of nectin family members comprises three Ig-like domains (V, C, C) . Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q96NY8
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-200 from the human protein was used as the immunogen for the PVRL4 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
NECT4/7271
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the PVRL4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PVRL4 antibody is available for research use only.
Storage Conditions
Aliquot the PVRL4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the PVRL4 antibody should be determined by the researcher.
Location
Cell surface, secreted
Image Legend
IHC staining of FFPE human placental tissue with PVRL4 antibody (clone NECT4/7271) . Negative control inset: PBS used instead of primary antibody to control for secondary Ab binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q96NY8

Nectin-4

NECT4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96NY8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NECTIN4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DQW3, Q96K15
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell junctionCell membraneMembraneSecreted

Disease

Disease variantEctodermal dysplasia

PTM

Disulfide bondGlycoprotein

Molecular function

Host cell receptor for virus entryReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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