Anti-Hu CD85d PE-Cy™7

• Description:

  CD85d is a type I transmembrane glycoprotein of the ILT/LIR family, which contains three intracellular ITIMs. It is expressed on NK cells, monocytes, macrophages, and weakly granulocytes. CD85d binds classic HLA class I molecules, and non-classic HLA-G1, and is involved in the suppression of NK cell-mediated cytotoxicity. Interaction between CD85d and trophoblast-specific HLA-G1 probably contributes to maternal tolerance of the fetus by inhibiting maternal leukocytes. Antigen presenting cells expressing CD85d and CD85k appear to be crucial to the generation of CD8+ suppressor T cells and CD4+ regulatory T cells.

• Certification:

  RUO

• Target Antigen:

  CD85d

• Clone:

  42D1

• Applications:

  FC (QC tested)

• Format:

  PE-Cy™7

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *MacDonald KP, Munster DJ, Clark GJ, Dzionek A, Schmitz J, Hart DN: Characterization of human blood dendritic cell subsets. Blood 2002 Dec 15;100 (13) :4512-20. , URL: https://pubmed.ncbi.nlm.nih.gov/12393628/, *Lu N, Li Y, Zhang Z, Xing J, Sun Y, Yao S, Chen L: Human semaphorin-4A drives Th2 responses by binding to receptor ILT-4. Nat Commun. 2018 Feb 21;9 (1) :742. , URL: https://pubmed.ncbi.nlm.nih.gov/29467366/, *Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ, Drakeley CJ, Ssewanyana I, Nankya F, Mayanja-Kizza H, Dorsey G, Greenhouse B: FCRL5 delineates functionally impaired memory B cells associated with plasmodium falciparum exposure. PLoS Pathog. 2015 May 19;11 (5) :e1004894. , URL: https://pubmed.ncbi.nlm.nih.gov/25993340/

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The rat monoclonal antibody 42D1 recognizes an extracellular epitope of human CD85d, a transmembrane glycoprotein expressed on NK cells, monocytes, macrophages, and weakly on granulocytes.

• Applications Notes:

  6

• Species:

  Human

• CAS Number:

  9007-83-4

• Isotype:

  Rat IgG2a kappa