DOCK2-IN-1

CAT: 0804-HY-153128-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-153128-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM) . DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1].
CAS Number
[4590-86-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DOCK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dock2-in-1.html
Concentration
10mM
Purity
98.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3
Molecular Formula
C16H11ClN2O2
Molecular Weight
298.72
Precautions
H302, H315, H319
References & Citations
[1]Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19 (4) :488-97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DOCK2

Related Products

CatalogName
HY-P88929DOCK2 Antibody (YA8613, Mouse)
HY-P82965-01DOCK2 Antibody (YA2710, Rabbit)
HY-RS18172Dock2 Mouse Pre-designed siRNA Set A
HY-RS24646Dock2 Rat Pre-designed siRNA Set A
HY-RS03924DOCK2 Human Pre-designed siRNA Set A
HY-171274-01DOCK5-IN-1
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-W032015S11-Bromooctane-1,1-d2

Alternative Products

CatalogName
BA5957-5DOCK2-IN-1
522344-01DOCK2
MBS7119108-01DOCK2 Antibody
DF8431-BPDOCK2 Peptide
YF-PA11406anti-DOCK2

Popular Products