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DOCK2-IN-1

CAT: 0804-HY-153128-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153128-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DOCK2-IN-1 (compound 3), a CPYPP analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1].
CAS Number
4590-86-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DOCK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dock2-in-1.html
Concentration
10mM
Purity
98.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3
Molecular Formula
C16H11ClN2O2
Molecular Weight
298.72
Precautions
H302, H315, H319
References & Citations
[1]Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19 (4) :488-97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DOCK2

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