NHTD

CAT: 0804-HY-164513Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-164513Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC) [1].

CAS Number

2540915-70-4

UNSPSC

12352005

Target

Phosphodiesterase (PDE) ; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nhtd.html

Smiles

CC(C)(C)C1=C(O)C(/C=N/NC(C2=C(O)C=C(O)C=C2)=O)=C(C(CCCC3)=C3O4)C4=C1

Molecular Formula

C24H26N2O5

Molecular Weight

422.47

References & Citations

[1]Leung EL, et al. Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer. Int J Cancer. 2019 Sep 1;145 (5) :1334-1345.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

Alternative Products

Catalog	Name
T200095-01	NHTD

NHTD

Alternative Products

Popular Products