Anti-Hu TCR gamma/delta APC

Anti-Hu TCR gamma/delta APC

• Background: The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.
• Specifications: The mouse monoclonal antibody B1 (also known as B1.1) recognizes an extracellular epitope of TCR gamma/delta, the subtype of T cell receptor expressed mainly in epithelial tissues and at the sites of infection.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human, Non-human primates
• Target Antigen: TCR gamma/delta
• Isotype: Igg1 κ
• Clone: B1
• Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.
• Validated Applications: FC
• Format: APC
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Pöllinger B, Junt T, Metzler B, Walker UA, Tyndall A, Allard C, Bay S, Keller R, Raulf F, Di Padova F, O'Reilly T, Horwood NJ, Patel DD, Littlewood-Evans A: Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans. J Immunol. 2011, 186:2602-2612., URL: http://www.jimmunol.org/content/186/4/2602.long ,*Bordignon M, Belloni Fortina A, Pigozzi B, Alaibac M: 947948 T cells as potential contributors to the progression of parapsoriasis to mycosis fungoides. Mol Med Rep. 2008 Jul-Aug1(4):485-8., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=bordignon+m+2008+1%3A485 ,*Correia DV, Fogli M, Hudspeth K, da Silva MG, Mavilio D, Silva-Santos B: Differentiation of human peripheral blood V9481+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells. Blood. 2011 Jul 28118(4):992-1001., URL: https://pubmed.ncbi.nlm.nih.gov/21633088/,*Lehmann FS, Terracciano L, Carena I, Baeriswyl C, Drewe J, Tornillo L, De Libero G, Beglinger C: In situ correlation of cytokine secretion and apoptosis in Helicobacter pylori-associated gastritis. Am J Physiol Gastrointest Liver Physiol. 2002 Aug283(2):G481-8., URL: https://pubmed.ncbi.nlm.nih.gov/12121897/,*Rodríguez-Gago M, de Heredia A, Ramírez P, Parrilla P, Aparicio P, Yélamos J: Human anti-porcine gammadelta T-cell xenoreactivity is inhibited by human FasL expression on porcine endothelial cells. Transplantation. 2001 Aug 1572(3):503-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=rodriguez-gago+m+2001+72%3A503,
• Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.