Osteostatin (human)

• Description :

  Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].

• Product Name Alternative :

  Human PTHrP (107-139)

• UNSPSC :

  12352209

• Target :

  Thyroid Hormone Receptor

• Type :

  Peptides

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/osteostatin-human.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC1=CN=CN1)NC([C@H](CC(O)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC(CNC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC(CNC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](CO)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CCCNC(N)=N)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C142H228N42O58

• Molecular Weight :

  3451.58

• References & Citations :

  [1]Lidia Ibáñez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23 (15) :8551.|[2]C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [137348-10-8]