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RSM3

CAT: 0804-HY-P10387-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10387-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RSM3, a stapled peptide, is a METTL3-METTL14 inhibitor with an Kd of 3.10 μM. RSM3 inhibits tumor growth while induces cell apoptosis. RSM3 can be used for study of cancer[1].
UNSPSC
12352209
Target
Apoptosis; METTL3
Type
Peptides
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rsm3.html
Purity
95.73
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : ≥ 25 mg/mL
Smiles
N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSCC1=CC=C2C=C1)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSCC3=CC=C2C=C3)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N
Molecular Formula
C130H218N54O26S3
Molecular Weight
3049.66
References & Citations
[1]Li Z, et al. A Stapled Peptide Inhibitor Targeting the Binding Interface of N6-Adenosine-Methyltransferase Subunits METTL3 and METTL14 for Cancer Therapy. Angew Chem Int Ed Engl. Published online April 12, 2024.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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