RSM-932A

• Description :

  RSM-932A (TCD-717) is a specific ChoKα inhibitor with IC50s of 1 and 33 μM for human recombinant ChoKα and ChoKβ enzymes, respectively. RSM-932A acts as the “first in humans” compound targeting ChoKα. RSM-932A is potent in vitro anti-proliferative and in vivo anti-tumoral activity against human xenografts in mice, showing high efficacy with low toxicity profiles[1][2][3].

• Product Name Alternative :

  TCD-717

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Choline Kinase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rsm-932a.html

• Purity :

  98.44

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CN(C1=C2C=CC=CC2=[N+](CC3=CC=C(C4=CC=C(C[N+]5=C6C=CC=CC6=C(N(C7=CC=C(Cl)C=C7)C)C=C5)C=C4)C=C3)C=C1)C8=CC=C(Cl)C=C8.[Br-].[Br-]

• Molecular Formula :

  C46H38Br2Cl2N4

• Molecular Weight :

  877.53

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  Streptococcus pneumonia

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [850807-63-5]