RSM-932A

• Description:

  RSM-932A (TCD-717) is a specific ChoKα inhibitor with IC50s of 1 and 33 μM for human recombinant ChoKα and ChoKβ enzymes, respectively. RSM-932A acts as the “first in humans” compound targeting ChoKα. RSM-932A is potent in vitro anti-proliferative and in vivo anti-tumoral activity against human xenografts in mice, showing high efficacy with low toxicity profiles[1][2][3].

• Product Name Alternative:

  TCD-717

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Choline Kinase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rsm-932a.html

• Purity:

  98.44

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CN (C1=C2C=CC=CC2=[N+] (CC3=CC=C (C4=CC=C (C[N+]5=C6C=CC=CC6=C (N (C7=CC=C (Cl) C=C7) C) C=C5) C=C4) C=C3) C=C1) C8=CC=C (Cl) C=C8.[Br-].[Br-]

• Molecular Formula:

  C46H38Br2Cl2N4

• Molecular Weight:

  877.53

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  Streptococcus pneumonia

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  850807-63-5