Human Parathyroid Hormone Recombinant

CAT: 0421-90231-ASize: 20 µgDry Ice: NoHazardous: No

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CAT#:0421-90231-ASize:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption, however, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein α subunits.Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

Description

Recombinant Human PTH-84 is a disulfide-linked homodimeric protein consisting of 84 amino acid residues, and migrates as an approximately 9 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human PTH mature chain was expressed inE. coli.

UniProt

P01270

Endotoxin

< 0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Purity

≥ 95% by SDS-PAGE and HPLC

Format

Lyophilized protein

Reconstitution

Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.

Shipping Conditions

Gel Packs or Dry Ice

Storage Conditions

The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.

Calculated Molecular Weight

9 kDa

Formulation

Lyophilized from a 0.2 µm filtered phosphate buffer solution, pH 7.

UniProtKB · P01270

Parathyroid hormone

PTHY_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P01270
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PTH
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PTH
EC number: —
Processing: Precursor
Secondary accessions: Q4VB48, Q9UD38

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Cleavage on pair of basic residues

Disease

Disease variant

Molecular function

Hormone

Cellular component

Secreted

Domain

Signal

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MBS191508-01	Recombinant Human Parathyroid Hormone (rHuPTH)
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