Human MCP-4 (CCL13) Recombinant

CAT: 0421-90214-BSize: 25 µgDry Ice: NoHazardous: No

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CAT#:0421-90214-BSize:25 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is member of a distinct, structurally-related subclass of CC chemokines. MCP-4/CCL13 is a major chemoattractants for eosinophils, basophils monocytes and T-lymphocytes. The MCP protein family bind to specific G-protein-coupled receptors, initiating a signal cascade within the cell. Expression of MCP-4/CCL13 mRNA and protein is greater in the sputum, epithelium, submucosal inflammatory cells and bronchoalveolar lavage fluid of asthmatics than in healthy individuals. Involvement of MCPs has also been demonstrated in renal inflammation and atopic dermatitis and the expression of this protein is also correlated with enhanced inflammatory immune responses during immunotherapy.

Description

Recombinant MCP-4 is a disulfide-linked monomeric protein consisting of 76 amino acid residues and migrates as an approximately 9 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human MCP-4 (CCL13) mature chain was expressed inE. coli.

UniProt

Q99616

Endotoxin

< 0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Purity

≥ 98% by SDS-PAGE and HPLC

Format

Lyophilized protein

Reconstitution

Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.

Shipping Conditions

Gel Packs or Dry Ice

Storage Conditions

The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.

Calculated Molecular Weight

9 kDa

Formulation

Lyophilized from a 0.2 µm filtered 20 mM Phosphate buffer, 100 mM NaCl, pH 7.5.

UniProtKB · Q99616

C-C motif chemokine 13

CCL13_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q99616
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CCL13
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: O95689, Q6ICQ6

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bondPyrrolidone carboxylic acid

Cellular component

Secreted

Domain

Signal

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Alternative Products

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OPSD00069-5UG	Recombinant MCP-4 / CCL13
327-P4-025	Recombinant Human CCL13/MCP-4
Z100649	Recombinant Human MCP-4 (CCL13)
MBS553048-01	Human MCP-4 (CCL13) Recombinant
P6614-5μg	Recombinant Human MCP-4/CCL13
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HY-P7245-01	MCP-4/CCL13, Human
MBS691757-01	Human MCP-4 (CCL13)
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