EGF Recombinant

• Background:

  EGF (Epidermal Growth Factor) is a growth factor of the EGF family, involved in cell growth and differentiation. It binds to EGFR (EGF receptor) with high affinity, inducing the formation of a dimer with tyrosine kinase activity able to regulate downstream signaling pathways. Abnormal expression of EGF and hyperactivation of EGFR can result in multiple diseases, ranging from psoriasis to schizophrenia. EGFR activation is also involved in cancer, with multiple strategies aimed at its inhibition. EGF can be used in the treatment of diabetic foot ulcers due to its wound healing roles. It has also attracted interest as a skin anti-aging product, as it can stimulate fibroblasts to produce collagen and elastin. EGF is thus a protein with multiple clinically relevant applications, and further studies will bring its importance to light.

• Description:

  Recombinant human EGF (Epidermal Growth Factor), encompassing amino acids 971- 1023. This protein was affinity purified.This product has beencited 7 times.

• UniProt:

  P01133

• Tag:

  None

• Applications:

  Useful for SDS-PAGE.

• Endotoxin:

  < 1 EU per µg of EGF.

• Purity:

  ≥ 90% by SDS-PAGE and HPLC analysis.

• Format:

  Powder

• Reconstitution:

  Perform a quick spin of the vial prior to reconstitution. Reconstitute in distilled water at 1 mg/ml.

• Shipping Conditions:

  -80°C

• Storage Conditions:

  At least 6 months at -80°C.

• Calculated Molecular Weight:

  6.2 kDa

• Formulation:

  Lyophilized  from  a  sterile  filtered  solution  containing  10  mM  Phosphate Buffered Saline (PBS), pH 7.4,138 mM NaCl, and 2.7 mM KCl.