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EGF Recombinant

CAT: 0421-90201-2Size: 500 µgDry Ice: YesHazardous: No
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CAT#:0421-90201-2Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EGF (Epidermal Growth Factor) is a growth factor of the EGF family, involved in cell growth and differentiation. It binds to EGFR (EGF receptor) with high affinity, inducing the formation of a dimer with tyrosine kinase activity able to regulate downstream signaling pathways. Abnormal expression of EGF and hyperactivation of EGFR can result in multiple diseases, ranging from psoriasis to schizophrenia. EGFR activation is also involved in cancer, with multiple strategies aimed at its inhibition. EGF can be used in the treatment of diabetic foot ulcers due to its wound healing roles. It has also attracted interest as a skin anti-aging product, as it can stimulate fibroblasts to produce collagen and elastin. EGF is thus a protein with multiple clinically relevant applications, and further studies will bring its importance to light.
Description
Recombinant human EGF (Epidermal Growth Factor), encompassing amino acids 971- 1023. This protein was affinity purified.This product has beencited 7 times.
UniProt
P01133
Tag
None
Applications
Useful for SDS-PAGE.
Endotoxin
< 1 EU per µg of EGF.
Purity
≥ 90% by SDS-PAGE and HPLC analysis.
Format
Powder
Reconstitution
Perform a quick spin of the vial prior to reconstitution. Reconstitute in distilled water at 1 mg/ml.
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
6.2 kDa
Formulation
Lyophilized  from  a  sterile  filtered  solution  containing  10  mM  Phosphate Buffered Saline (PBS), pH 7.4,138 mM NaCl, and 2.7 mM KCl.

UniProtKB · P01133

Pro-epidermal growth factor

EGF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01133
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EGF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
EGF
EC number
—
Processing
Precursor
Secondary accessions
B4DRK7, E7EVD2, E9PBF0, Q52LZ6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantPrimary hypomagnesemia

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

Growth factor

Cellular component

Membrane

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