Human Interleukin-11 Recombinant

CAT: 0421-90176-ASize: 2 µgDry Ice: NoHazardous: No
CAT#:0421-90176-ASize:2 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL-11 is secreted by bone marrow stromal cells (fibroblasts) and is produced also by a number of mesenchymal cells. The IL-11 receptor (alpha chain) utilizes gp130 as its signal transducer, which is also a component of other cytokine receptors. The alpha chain of the IL-11 receptor has been identified independently as Etl2. IL-11 promotes primary and secondary immune responsesin vitroandin vivoand modulates antigen-specific antibody reactions. IL-11 promotes the proliferation of IL-6 dependent plasmacytoma cell lines in the presence of neutralizing IL-6 antibodies. IL-11 also stimulates the T-cell dependent development of IgG-secreting B-cells in spleen cell cultures. IL-11 inhibits the differentiation of pre- adipocytes. It induces the synthesis of some acute phase proteins by hepatocytes.
Description
Recombinant human interleukin-11 (IL-11), also known as oprelvekin, is a disulfide-linked monomeric protein consisting of 180 amino acids and migrates as an approximately 19 kDa protein under reducing and non-reducing conditions. Optimized DNA sequence encoding human IL-11 mature chain was expressed inE. coli.
UniProt
P20809
Endotoxin
Endotoxin level was found to be < 0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Purity
≥ 97% by SDS-PAGE and HPLC
Format
Lyophilized protein
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to concentration not less than 0.1 mg/ml. This can then be diluted into other buffers
Shipping Conditions
Gel Packs or Dry Ice
Storage Conditions
The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.
Calculated Molecular Weight
19 kDa
Formulation
Lyophilized from 0.2 µm filtered phosphate buffered solution in 2.5% glycine, pH 4.5.

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