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Caspase8, His-tag Recombinant

CAT: 0421-80114-2Size: 50 µgDry Ice: YesHazardous: No
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CAT#:0421-80114-2Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspase-8 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Caspase-8 has been associated with chronic inflammation and neurodegenerative disorders including Alzheimer’s, Huntington’s, and Parkinson’s.
Description
Human Caspase 8 (CASP8), GenBank Accession No. NM_001228), a.a. 200 - 496 (end), with C-terminal His-tag, MW=34.5 kDa, expressed in anE. colicell expression system. Procaspase-8 is autocleaved between the prodomain and large protease subunit (p18) . The cleavage product, p30, contains both the large (p18) and small (p10 [His-tag]) protease subunits. p30 is further processed to the p18 and p10 subunits, which dimerize to form active enzyme.
UniProt
Q14790
Tag
C-terminal His-tag
Purity
≥ 90%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
> 6 months at -80°C.
Calculated Molecular Weight
See Description
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 3 mM DTT and 20% glycerol.

UniProtKB · Q14790

Caspase-8

CASP8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14790
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-8
EC number
3.4.22.61
Processing
Precursor
Secondary accessions
O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinZymogen

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interaction

Cellular component

Cell projectionCytoplasmNucleus

Disease

Disease variant

Molecular function

HydrolaseProteaseThiol protease

Domain

Repeat

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