NSC697923

• Background :

  NSC697923 selectively inhibits PMA-induced NF-?B activation, and also inhibits I?Bα phosphorylation by both RANKL and LPS. NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-?B activity in ABC-DLBCL cells. In addition, NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, and also induces apoptosis of primary DLBCL cells. In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation.

• Description :

  NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. It is believed to act by disrupting formation of the Ubc13:Ub conjugate. Shown to inhibit proliferation and survival of certain B-cell lymphoma cells.

• Solubility :

  Soluble in DMSO (20 mg/mL) .

• Molecular Formula :

  C11H9NO5S

• Shipping Conditions :

  Room Temperature (continental US) or Gel Packs

• Storage Conditions :

  Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

• Calculated Molecular Weight :

  267.3 Da

• CAS Number :

  343351-67-7