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Elesclomol (STA-4783)

CAT: 0421-27748-2Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0421-27748-2Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS) and the induction of unmanageable levels of oxidative stress. Elesclomol exhibits autitumor activity against a broad spectrum of types of cancer cell in human tumor xengograft models due to its excessive ROS production and elevated levels of oxidative stress leading to the death of cancer cells. Elesclomol is currently being studies as a novel cancer therapeutic, in which it has demonstrated ability to prolong progression-free survival in study subjects. Elesclomol induces oxidative stress by provoking a buildup of reactive oxygen species within cancer cells. Elesclomol requires a redox active metal ion to function; the Cu (II) complex is 34 times more potent than the Ni (II) complex and 1040-fold more potent than the Pt (II) complex.
Description
Elesclomol induces oxidative stress and triggers mitochondrial-induced apoptosis in cancer cells.
CAS Number
488832-69-5
Solubility
Soluble in DMSO
Molecular Formula
C19H20N4O2S2
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
400.5 Da

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