WP1130

CAT: 0421-27722-1Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0421-27722-1Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

A partially-selective, cell permeable DUB inhibitor that directly inhibits USP9x, USP5, USP14, and UCH37. WP1130, derived from the tyrphostin AG490, was identified in a screen for molecules that suppress IL-3 and IL-6 activation of STAT molecules. It has been subsequently shown to induce rapid accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, block JAK2 signaling through JAK2 ubiquitination and subsequent downregulation, and exhibit antiviral activity through activation of the unfolded protein response (UPR) . Typical concentration for cell culture experiments is 5 μM.

CAS Number

856243-80-6

Applications

Suitable for cell-based studies of USP function.

Purity

≥ 98% by TLC.

Format

Pale yellow powder

Solubility

Soluble in DMSO (45 mg/mL) ; Ethanol (25 mg/mL)

Molecular Formula

C19H18BrN3O

Shipping Conditions

Room Temperature or Gel Packs

Calculated Molecular Weight

384.3 Da

Chemical Information

Degrasyn

a JAK2 kinase inhibitor that induces rapid degradation of c-Myc protein in MM-1 multiple myeloma and other tumor cell lines; structure in first source

CAS Number	856243-80-6
PubChem CID	11222830
IUPAC Name	(E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]prop-2-enamide
Molecular Formula	C19H18BrN3O
Molecular Weight	384.3
XLogP	4.3
Topological Polar Surface Area	65.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Heavy Atom Count	24
Formal Charge	0
Complexity	490

SMILES

CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

InChI

InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1

InChIKey

LIDOPKHSVQTSJY-VMEIHUARSA-N

Chemical Structure

2D Structure

CAS: 856243-80-6

CID: 11222830

Formula: C19H18BrN3O

MW: 384.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	384.3
XLogP3	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	383.06332
Monoisotopic Mass	383.06332
Topological Polar Surface Area	65.8 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	490
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
sc-364650A	WP1130
A10988-100	WP1130 100mg
C08384-1g	Degrasyn (WP1130)
MBS386407-01	WP1130 (Degrasyn)
MBS132467-01	WP1130, Degrasyn
A10988-50	WP1130 50mg

WP1130

Chemical Information

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