PS-341 (MG-341)

• Description:

  PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib. PS-341 is a reversible, cell permeable, potent, and selective proteasome inhibitor (Ki=0.6 nM) . It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50=7 nM) . Inhibits TNF synthesis and FGF-induced angiogenesis.

• Applications:

  Useful for as a potent, cell permeable proteasome inhibitor for drug discovery research.

• Purity:

  > 98% by HPLC.

• Format:

  White powder

• Solubility:

  Soluble in DMSO

• Molecular Formula:

  C19H25BN4O4

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.

• Calculated Molecular Weight:

  384.2 Da

• CAS Number:

  179324-69-7