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MOMA-341

CAT: 0804-HY-175750-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175750-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MOMA-341 is a selective Werner RecQ like helicase (WRN) inhibitor. MOMA-341 binds to WRN at cysteine 727 through an allosteric and ATP-competitive binding mechanism. MOMA-341 induces DNA damage, cell death, and tumor regressions in mismatch-repair deficient (dMMR) /microsatellite instability high (MSI-H) mice model. MOMA-341 has antitumor activity, promising for advanced and metastatic solid tumors research[1].
CAS Number
3078276-74-8
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
C=CC(N1CCC2=NN(C3=C2[C@@H](N(CC3)C(C4=C(C(F)=C(N=C4)C(F)(F)F)N)=O)C1)C5=CC=C(C=C5O)C6CC6)=O
Molecular Formula
C28H26F4N6O3
Molecular Weight
570.54
References & Citations
[1]Tubbs A, et al. Direct measurement of TA repeat expansions significantly outperforms MSI-H status as a predictor of sensitivity to the novel WRN inhibitor MOMA-341[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 4205-4205.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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