Spike Neutralizing Antibody (Clone G10xA5) (SARS-CoV-2)

• Description:

  This monoclonal antibody recognizes the SARS-CoV-2 Spike (B.1.1.529, Omicron Variant) RBD Domain and the S1+S2 trimeric complex to neutralize its interaction with ACE2 [Table of variants]. The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Spike protein. This neutralizing antibody has been functionally tested using the SARS-CoV-2 Spike RBD (B.1.1.529, Omicron Variant) :ACE2 Inhibitor Screening Colorimetric Assay Kit (BPS Bioscience #78339) .

• Applications:

  This product is for research use only.  It is not suitable for human, diagnostic or therapeutic use. The monoclonal neutralizing IgG can be used for functional assays to block SARS-CoV-2 Spike protein and ACE2 binding.

• Purification:

  Protein A affinity chromatography

• Format:

  Aqueous buffer solution

• Shipping Conditions:

  -20°C (Gel Packs or Dry Ice)

• Storage Conditions:

  Store in aliquots at -20°C.  Stable for at least 6 months from date of receipt.

• Calculated Molecular Weight:

  ~150 kDa

• Specificity:

  The antibody recognizes the B.1.1.529 Omicron variant RBD domain and the S1+S2 trimeric protein.  It has not been tested on other spike variants, or on the S1 subunit.

• Formulation:

  1x PBS, 0.2% BSA

• CAS Number:

  9007-83-4