Spike Neutralizing Antibody (Clone LxC1-G10) (SARS-CoV-2)

• Description:

  This human monoclonal antibody recognizes SARS-CoV-2 full-length spike proteins in both the monomeric (S1) and native trimeric conformation. This antibody has been demonstrated to cross-react with the following SARS-CoV-2 spike proteins:Wild-type Spike Trimer (BPS Bioscience #100728) Alpha B.1.1.7 Spike Trimer (BPS Bioscience #510334) Beta B.1.351 Spike Trimer (BPS Bioscience #510333) Beta B.1.351Δ242-244 Spike Trimer (BPS Bioscience #101091) Gamma P.1 Spike Trimer (BPS Bioscience #100989) Delta B.1.617.2 Spike Trimer (BPS Bioscience #101147) Delta Plus B.1.617.2.1 Spike Trimer (BPS Bioscience #101165) Wild-type S1 Protein (BPS Bioscience #100730) Delta B.1.617.2 S1 Protein (BPS Bioscience #101151) Delta Plus B.1.617.2.1 S1 Protein (BPS Bioscience #101179) Gamma P.1 S1 Protein (BPS Bioscience #101079) [Table of variants]The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Sike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike Trimer: ACE2 Inhibitor Screening Kits (available for purchase) .

• CAS Number:

  9007-83-4

• Applications:

  This product is for research use only. It is not suitable for human, diagnostic or therapeutic use. The human monoclonal neutralizing IgG can be used for functional assays to block SARS-CoV-2 Spike protein and ACE2 binding.

• Purification:

  Protein A

• Format:

  Aqueous buffer solution.

• Shipping Conditions:

  -20°C or-80°C (Gel Packs or Dry Ice)

• Storage Conditions:

  -20°C.  Stable for at least 6 months from date of receipt.

• Calculated Molecular Weight:

  150 kDa

• Specificity:

  The antibody neutralizes the wildtype, Alpha B.1.1.7, Beta B.1.351, Gamma P.1, Delta B.1.617.2 and Delta Plus B.1.617.2.1 variant trimeric proteins. Not tested on other variants or on monomeric Spike RBD protein.

• Formulation:

  1x PBS, 0.2% BSA