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Fluorogenic PTP1B (Catalytic Domain) Assay Kit

CAT: 0421-79764Size: 96 ReactionsDry Ice: YesHazardous: No
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CAT#:0421-79764Size:96 Reactions
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Description
Protein phosphorylation is one of the most important post-translational modification processes. Phosphorylation is reversibly regulated by Protein Kinases (PKs) and Protein Phosphatases (PTPs) . PTP1B (PTPN1) is known to catalyze dephosphorylation of insulin receptor kinases and plays a critical role in insulin signaling. The Fluorogenic PTP1B (Catalytic Domain) Assay Kit is designed to inhibitors of the catalytic region of PTP1B in a homogeneous assay with no time-consuming washing steps. Note: To identify inhibitors of the regulatory region of PTP1B, please use our Fluorogenic PTP1B (Full Length) Assay Kit, #79766) .Need us to run inhibitor screens or profile your compounds against PTP1B (Catalytic Domain) ? Check out ourProtein Tyrosine Phosphatase Screening Services.
UniProt
P18031
Format
Catalog #ComponentAmountStorage30010Recombinant Human PTP1B (1-321) *≥1 µg-80°CAvoid freeze/ thaw cycles!781830.5 mM PTP1B Substrate50 µl-80°C797165X PTP Assay Buffer20 ml-20°C0.5 M DTT200 µl-20°C79685Black, low binding black microtiter plate1Room Temperature*Additional material has been provided for ease of retrieval.
Shipping Conditions
-80°C
Storage Conditions
6 months from date of receipt when stored as directed.

UniProtKB · P18031

Tyrosine-protein phosphatase non-receptor type 1

PTN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18031
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.48
Processing
—
Secondary accessions
Q5TGD8, Q9BQV9, Q9NQQ4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationOxidationPhosphoproteinS-nitrosylation

Cellular component

Endoplasmic reticulumMembrane

Molecular function

HydrolaseProtein phosphatase

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