CD38 Inhibitor Screening Assay Kit (Hydrolase Activity)

• Background:

  CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic β cells. The major enzymatic activity of CD38 is the hydrolysis of NAD. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.

• Description:

  The CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) is designed to measure the glycohydrolase activity of CD38 for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate N6-etheno-NAD (ε-NAD), and CD38 assay buffer for 100 enzyme reactions. In addition, the kit includes the CD38 inhibitor apigenin for use as a control inhibitor.Need us to run inhibitor screens or profile your compounds against CD38 (Hydrolase Activity) ? Check out ourImmunotherapy Biochemical Screening Services.

• UniProt:

  P28907

• Format:

  CatalogNumberReagentAmountStorage71277CD38, His-Tag (Human), HiP™1 µg-80°CAvoidmulitplefreeze/thawcycles!4x CD38 hydrolase buffer3 ml-20°CCD38 substrate (ε-NAD) 50 µl-20°CApigenin (50 mM DMSO) 10 µl-20°C79685Black 96-well plate1Room Temp.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Up to 6 months from date of receipt, when stored as recommended.