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MAP3K14 Kinase Assay Kit

CAT: 0421-78440Size: 96 ReactionsDry Ice: YesHazardous: No
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CAT#:0421-78440Size:96 Reactions
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAP3K14 (mitogen-activated protein kinase kinase kinase 14, also known as NF-kappa-beta-inducing kinase or NIK) is a Serine/Threonine Kinase of the MAPKK kinase family. This kinase is known for its non-canonical activation of transcription factor NFκB. Expressed in immune cells, it is activated by the interleukin-1 receptors and by receptors of the tumor-necrosis/nerve-growth factor (TNF/NGF) family and plays a role in the innate and adaptive immune response and regulates inflammation. Loss of MAP3K14 expression is associated with immune defects, whereas overexpression correlates with inflammation, metabolic diseases, or cancer.
Description
The MAP3K14 Kinase Assay Kit is designed to measure MAP3K14 kinase activity for screening and profiling applications using ADP-Glo®as a detection reagent.
UniProt
Q99558
Applications
Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Format
Catalog #NameAmountStorage40090MAP3K14*2.5 µg-80°C79334Kinase assay buffer 1 (5x) 1.5 ml-20°C79686ATP (500 µM) 100 µl-20°C40535Myelin basic protein (MBP), 5 mg/ml100 µl-20°C79696White 96-well plate1Room Temp*The concentration of the protein is lot-specific and will be indicated on the tube
Shipping Conditions
-80°C
Storage Conditions
This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Notes
Troubleshooting GuideFor questions, please email[email protected]
Contraindications
The final concentration of DMSO in the assay should not exceed 1%.

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Alternative Products

CatalogName
485358MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14)
abx126120-01Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) Antibody
E47R0074MAP3K14/NFkB Inducing Kinase Rabbit pAb
bs-0074R-TRMAP3K14/NFkB Inducing Kinase Polyclonal Antibody
TS407616P5NFkB Inducing Kinase NIK (MAP3K14) CytoSection
MBS643593-01Map3k14, CT (Map3k14, Nik, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, Serine/threonine-protein kinase NIK)
MBS6318595-01Map3k14, CT (Map3k14, Nik, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, Serine/threonine-protein kinase NIK) (APC)
SL0074R-01Rabbit Anti-MAP3K14/NFkB Inducing Kinase antibody
MBS6318596-01Map3k14, CT (Map3k14, Nik, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, Serine/threonine-protein kinase NIK) (Biotin)
MBS6318604-01Map3k14, CT (Map3k14, Nik, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, Serine/threonine-protein kinase NIK) (PE)

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