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EIF2AK2 Kinase Assay Kit

CAT: 0421-78433Size: 96 ReactionsDry Ice: YesHazardous: No
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CAT#:0421-78433Size:96 Reactions
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2, also known as PKR) is a protein kinase shown to be involved in HIV/gp120-associated neurodegeneration.EIF2AK2 acts as a critical mediator of gp120 neurotoxicity and is a substrate for a family of protein kinases that respond to various forms of environmental stress. EIF2AK2 plays a critical role in mRNA translation, cell proliferation and apoptosis. A novel cross-talk between the EIF2AKs and p53 may have implications in cell proliferation and tumorigenesis.
Description
The EIF2AK2 Kinase Assay Kit is designed to measure EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2) kinase activity for screening and profiling applications using ADP-Glo™ as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant EIF2AK2 kinase (amino acids 252-end), kinase substrate, ATP and kinase assay buffer for 100 enzyme reactions.
UniProt
P19525
Applications
Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Format
Catalog #NameAmountStorage40058EIF2AK2, GST-tag*1.5 µg-80°C793345x Kinase Assay Buffer 11.5 ml-20°C79686500 µM ATP100 µl-20°C78514Myelin basic protein (MBP), 5 mg/ml100 µl-20°C79696White 96-well plate1Room Temp*The concentration of the protein is lot-specific and will be indicated on the tube
Shipping Conditions
-80°C
Storage Conditions
This assay kit will perform optimally for up to6 monthsfrom date of receipt when the materials are stored as directed.
Notes
Troubleshooting GuideVisitbpsbioscience.com/assay-kits-faqfor detailed troubleshooting instructions. For all further questions, please email[email protected]
Contraindications
The final concentration of DMSO in the assay should not exceed 1%.

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