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Ash2L, His-tag Recombinant

CAT: 0421-71201Size: 50 µgDry Ice: YesHazardous: No
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CAT#:0421-71201Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ash2L (Absent, small or homeotic-like protein), is a subunit of histone H3K4 lysine methyltransferase complex, such as the MLL1 (mixed lineage leukemia 1) and MLL3 complex. It belongs to the trithorax family of proteins and regulates cell proliferation and cell fate. For instance, it is critical to regulate the transition from pluripotency to a differentiated cell via its effects on pluripotency genes. This protein has been linked to cancer, as it interacts with MYC and RAS (rat sarcoma virus), and it is overexpressed in several solid tumors and leukemia cell lines. Trying to understand the role of this protein and how to best use its properties to develop new therapeutics is an exciting and ongoing field of research.
Description
Recombinant human full length Ash2L (Absent, small or homeotic-2 like protein), amino acids 2-534. This construct contains an N-terminal His-tag (6xHis) . This protein was affinity purified.
UniProt
Q9UBL3
Tag
N-terminal His-tag
Applications
Useful for SDS-PAGE.
Purity
≥ 90%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
61 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20,20% glycerol, and variable imidazole

UniProtKB · Q9UBL3

Set1/Ash2 histone methyltransferase complex subunit ASH2

ASH2L_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UBL3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ASH2L
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K7C3, D3DSW9, O60659, O60660, Q96B62
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorDNA-binding

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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