PDE4D2, GST-tag Recombinant

• Background:

  Phosphodiesterases (PDEs) play an important role in the dynamic regulation of the second messengers cAMP and cGMP signaling, by hydrolyzing them. The PDE4D gene encodes 9 different isoforms involved in transmitting immune responses and neuronal signaling. At the physio-pathological level, PDE4D is associated with asthma, is a regulator of airway smooth-muscle contractility, and a potential risk predictor for ischemic stroke.

• Description:

  Recombinant human PDE4D2 (phosphodiesterase 4D2), encompassing amino acids 2-507 (end) . This construct contains an N-terminal GST-tag. This protein was affinity purified.This product has beencited 17 times.

• UniProt:

  Q08499-5

• Tag:

  N-terminal GST-tag

• Applications:

  Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

• Purity:

  ≥ 86%

• Format:

  Aqueous buffer solution

• Shipping Conditions:

  -80°C

• Storage Conditions:

  > 6 months at -80°C.

• Calculated Molecular Weight:

  84 kDa

• Formulation:

  40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% Glycerol and 16 mM Glutathione.