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Resminostat

CAT: 0804-HY-14718-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14718-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Resminostat (RAS2410; 4SC-201) is a potent inhibitor of HDAC1, HDAC3 and HDAC6, with mean IC50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC50 of 877 nM.
CAS Number
864814-88-0
Product Name Alternative
RAS2410; 4SC-201
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/resminostat.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1
Molecular Formula
C16H19N3O4S
Molecular Weight
349.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Mandl-Weber S, et al. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol. 2010 May;149 (4) :518-28.|[2]Enzenhofer E, et al. Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines. Head Neck. 2017 May;39 (5) :900-907.|[3]Peng X, et al. mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat. Biochem Biophys Res Commun. 2016 Sep 2;477 (4) :556-562.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
HDAC1; HDAC3; HDAC6; HDAC8
Citation 01
Acta Pharmacol Sin. 2022 Feb;43 (2) :457-469.|Hong Kong Polytechnic University. 2025.|Methods Mol Biol. 2018:1711:351-398.

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