IL23A rabbit pAb

• Background:

  Developmental stage:Expressed by newborns dendritic cells., function:Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis., induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors., similarity:Belongs to the IL-6 superfamily., subcellular location:Secreted upon association with IL12B., subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23., tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level) .

• Description:

  Developmental stage: Expressed by newborns dendritic cells. function: Associates with IL12B to form the IL-23 interleukin, an heterodimeric Cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. induction: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors. similarity: Belongs to the IL-6 superfamily. subcellular location: Secreted upon association with IL12B. subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

• Synonyms:

  Interleukin-23 subunit alpha (IL-23 subunit alpha;IL-23-A;Interleukin-23 subunit p19;IL-23p19)

• UniProt:

  Q9NPF7

• Cellular Locus:

  Secreted. Secreted upon association with IL12B.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human IL23A

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Secreted . Secreted upon association with IL12B.

• Other Product Names:

  Interleukin-23 subunit alpha (IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19)

• SwissProt (Human):

  Q9NPF7