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MBNL3 Antibody

CAT: 0800-V9208-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9208-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells
UniProt
Q9NUK0
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human MBNL3 protein was used as the immunogen for the MBNL3 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
PCRP-MBNL3-1D11
Applications
FACS
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MBNL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MBNL3 antibody is available for research use only.
Storage Conditions
Aliquot the MBNL3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MBNL3 antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using MBNL3 antibody (clone PCRP-MBNL3-1D11) . These results demonstrate the foremost specificity of the PCRP-MBNL3-1D11 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

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