Leptin Receptor Antibody / LEPR / Ob-R

• Description:

  The Ob gene encodes the protein leptin. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor.

• Specifications:

  Immunohistochemistry (FFPE) : 1-2 µg/mL

• UniProt:

  P48357

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 335-425 was used as the immunogen for the Leptin Receptor antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  LEPR/4301

• Applications:

  IHC-P

• Purity:

  Protein A/G affinity

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Aliquot the Leptin Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This Leptin Receptor antibody is available for research use only.

• Storage Conditions:

  Aliquot the Leptin Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

• Applications Notes:

  Optimal dilution of the Leptin Receptor antibody should be determined by the researcher.

• CAS Number:

  9007-83-4

• Location:

  Secreted, Cell surface

• Image Legend:

  Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using Leptin Receptor antibody (clone LEPR/4301) . These results demonstrate the foremost specificity of the LEPR/4301 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.