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Recombinant MSH6 Antibody

CAT: 0800-V9141-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9141-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P52701
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 374-540 was used as the immunogen for the recombinant MSH6 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RMSH6/6846
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant MSH6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant MSH6 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant MSH6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant MSH6 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human small intestine tissue with recombinant MSH6 antibody (clone rMSH6/6846) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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