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TGF-a Antibody

CAT: 0800-V9085SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9085SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody reacts with the C-terminus of TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. TGF-a is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P01135
Host
Mouse
Reactivity
Human
Immunogen
A 17-amino acid peptide from the C-terminus of the rat protein was used as the immunogen for this TGF a antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM357
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the TGF-a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TGF-a antibody is available for research use only.
Storage Conditions
Store the TGF-a antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
The optimal dilution of the TGF-a antibody for each application should be determined by the researcher.
Location
Cytoplasmic and Extracellular (secreted)
Image Legend
IHC staining of FFPE human testicular carcinoma with TGF-a antibody (clone SPM357) . HIER: pH 9 10mM Tris with 1mM EDTA.

UniProtKB · P01135

Protransforming growth factor alpha

TGFA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01135
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TGFA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K286, Q15577, Q53SK7, Q9BS56, Q9UEI3, Q9UKM1, Q9UKM2, Q9UKM3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinLipoproteinPalmitate

Domain

EGF-like domainSignalTransmembraneTransmembrane helix

Molecular function

Growth factorMitogen

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