Products for Research Use Only
RegisterLogin

SUMO-2/3 Antibody

CAT: 0800-V9080-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V9080-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
This mAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer s disease.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-4 µg/mL for 30 min at RT
UniProt
P61956
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this SUMO-2/3 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM572
Applications
IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the SUMO-2/3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This SUMO-2/3 antibody is available for research use only.
Storage Conditions
Store the SUMO-2/3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Predominantly nuclear with some cytoplasmic
Image Legend
Immunofluorescent testing of PFA-fixed human HepG2 cells with SUMO2/3 antibody (green, clone SPM572) and Phalloidin (red) .

UniProtKB · P61956

Small ubiquitin-related modifier 2

SUMO2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61956
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SUMO2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SUMO-2
EC number
—
Processing
Precursor
Secondary accessions
B2R4I2, P55855, Q32Q42, Q6IPZ6, Q96HK1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Host-virus interactionUbl conjugation pathway

Cellular component

Nucleus

Related Products

CatalogName
F42017-0.08MLSUMO-3 Antibody
F42017-0.4MLSUMO-3 Antibody
V7051-100UGSUMO-2 Antibody
F42016-0.08MLSUMO-2 Antibody
V2860-100UGSUMO-2 Antibody
V7051-20UGSUMO-2 Antibody
F52344-0.4MLSUMO-2 Antibody
V2860IHC-7MLSUMO-2 Antibody
V7051IHC-7MLSUMO-2 Antibody
V2860SAF-100UGSUMO-2 Antibody

Alternative Products

CatalogName
49224-01Sumo 2+3 Antibody
GTR18292206SUMO-2/3 Antibody
MBS9456892-01Sumo 2+3 Conjugated Antibody
34-165SUMO-2/3 Antibody [SPM572]
ATGA0547-050Human SUMO 2/3 antibody
BS91301Sumo 2/3 polyclonal antibody
MBS9461810-01Sumo 2+3 Antibody HRP Conjugated
OM637635-01Sumo 2+3 [JJ087-04] Antibody
HY-P87316Sumo 2+3 Antibody (YA6999, Rabbit)
MBS438155-01SUMO-2/3 Mouse Monoclonal Antibody

Popular Products