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Anti-ACTH Antibody / Synacthen

CAT: 0800-V9067-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V9067-20UGSize:20 µg
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Description
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to Synacthen (aa1-24 of ACTH) ; does not react with CLIP (aa17-39 of ACTH) . POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs) . It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P01189
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 1-24 of the human protein were used as the immunogen for this anti-ACTH antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM333
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the anti-ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This anti-ACTH antibody is available for research use only.
Storage Conditions
Store the anti-ACTH antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The optimal dilution of the anti-ACTH antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human pituitary gland with anti-ACTH antibody (clone SPM333) .

UniProtKB · P01189

Pro-opiomelanocortin

COLI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01189
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POMC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
POMC
EC number
—
Processing
Precursor
Secondary accessions
P78442, Q53T23, Q9UD39, Q9UD40
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationAmidationCleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoprotein

Molecular function

EndorphinHormone

Disease

Obesity

Cellular component

Secreted

Domain

Signal
Product Datasheet
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