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Anti-CD56 Antibody

CAT: 0800-V9055SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9055SAF-100UGSize:100 µg
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Description
Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas) . It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma) . Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P13591
Host
Mouse
Reactivity
Human
Immunogen
A membrane preparation of small cell lung carcinoma was used as the immunogen for this anti-CD56 antibody. This mAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM489
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the anti-CD56 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This anti-CD56 antibody is available for research use only.
Storage Conditions
Store the anti-CD56 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cell surface, cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human colon stained with anti-CD56 antibody (SPM489)

UniProtKB · P13591

Neural cell adhesion molecule 1

NCAM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13591
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NCAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
N-CAM-1, NCAM-1
EC number
—
Processing
Precursor
Secondary accessions
A8K8T8, P13592, P13593, Q05C58, Q15829, Q16180, Q16209, Q59FL7, Q86X47, Q96CJ3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinGPI-anchorLipoproteinPhosphoprotein

Molecular function

Host cell receptor for virus entryReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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