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Chromogranin A Antibody

CAT: 0800-V9009-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V9009-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P10645
Host
Mouse
Reactivity
Human
Immunogen
Human pheochromocytoma cells were used as the immunogen for this Chromogranin A antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM585
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Chromogranin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Chromogranin A antibody is available for research use only.
Storage Conditions
Store the Chromogranin A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Finely granular cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human small cell lung carcinoma stained with Chromogranin A antibody (SPM585)

UniProtKB · P10645

Chromogranin-A

CMGA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10645
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHGA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CgA
EC number
—
Processing
Precursor
Secondary accessions
B2R9E9, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AmidationCleavage on pair of basic residuesDisulfide bondGlycoproteinOxidationPhosphoproteinProteoglycanSulfation

Molecular function

AntibioticAntimicrobialFungicide

Ligand

Calcium

Cellular component

Cytoplasmic vesicleSecreted

Domain

Signal
Product Datasheet
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