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MALT1 Antibody

CAT: 0800-V9006IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V9006IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT-1) is found in extranodal low-grade B cell lymphomas. The gene encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT-1 gene and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18) (q21; q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT-1 caspase-like domain. MALT-1 mRNA is found in pre-B cells, mature B cells and plasma cells.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q9UDY8
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 701-808 from the human protein were used as the immunogen for this MALT1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM578
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the MALT1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MALT1 antibody is available for research use only.
Storage Conditions
Store the MALT1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with MALT1 antibody (clone SPM578) .

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