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P27Kip1 Antibody

CAT: 0800-V9001IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V9001IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This mAb recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P46527
Host
Mouse
Reactivity
Human
Immunogen
Mouse p27Kip1 protein was used as the immunogen for this p27 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM348
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the p27Kip1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This p27Kip1 antibody is available for research use only.
Storage Conditions
Store the p27Kip1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Nuclear
Image Legend
IHC analysis of formalin-fixed, paraffin-embedded human prostate carcinoma stained with p27 antibody (clone SPM348) .

UniProtKB · P46527

Cyclin-dependent kinase inhibitor 1B

CDN1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P46527
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDKN1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q16307, Q5U0H2, Q9BUS6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Cell cycle

Cellular component

CytoplasmEndosomeNucleus

PTM

PhosphoproteinUbl conjugation

Molecular function

Protein kinase inhibitor

Disease

Tumor suppressor
Product Datasheet
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