PU.1 Antibody / SPI1

PU.1 Antibody / SPI1

• Description: PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.
• CAS Number: 9007-83-4
• UniProt: P17947
• Host: Mouse
• Immunogen: A portion of amino acids 16-170 was used as the immunogen for the PU.1 antibody.
• Clonality: Monoclonal
• Isotype: IgG1
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Aliquot the PU.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This PU.1 antibody is available for research use only.