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PU.1 Antibody / SPI1

CAT: 0800-V8999SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8999SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P17947
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 16-170 was used as the immunogen for the PU.1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
PU1/2118
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the PU.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PU.1 antibody is available for research use only.
Storage Conditions
Aliquot the PU.1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the PU.1 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC staining of FFPE human colon carcinoma tissue with PU.1 antibody (clone PU1/2118) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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