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PECAM1 Antibody / CD31

CAT: 0800-V8845-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V8845-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P16284
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 625-738 was used as the immunogen for the PECAM1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
PECAM1/3534
Applications
FACS, IF, WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the PECAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PECAM1 antibody is available for research use only.
Storage Conditions
Aliquot the PECAM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the PECAM1 antibody should be determined by the researcher.
Location
Cell surface and cytoplasm of endothelial cells
Image Legend
IHC staining of FFPE human tonsil tissue with PECAM1 antibody (clone PECAM1/3534) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P16284

Platelet endothelial cell adhesion molecule

PECA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16284
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PECAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PECAM-1
EC number
—
Processing
Precursor
Secondary accessions
A0A075B738, A8K3S7, D3DU31, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionPhagocytosis

Cellular component

Cell junctionCell membraneMembrane

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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