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CD40L Antibody / TRAP / CD154

CAT: 0800-V8828-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V8828-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 2-4 µg/mL
UniProt
P29965
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 108-261 was used as the immunogen for the CD40L antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CD40LG/4675
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CD40L antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD40L antibody is available for research use only.
Storage Conditions
Aliquot the CD40L antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD40L antibody should be determined by the researcher.
Location
Cell surface, Secreted
Image Legend
IHC staining of FFPE human liver carcinoma in colon tissue with CD40L antibody (clone CD40LG/4675) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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