Recombinant SDHB Antibody

CAT: 0800-V8826SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V8826SAF-100UGSize:100 µg
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Description
Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P21912
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human SDHB was used as the immunogen for the recombinant SDHB antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
SDHB/6697R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the recombinant SDHB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant SDHB antibody is available for research use only.
Storage Conditions
Aliquot the recombinant SDHB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant SDHB antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human heart tissue with recombinant SDHB antibody (clone SDHB/6697R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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