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B7-H6 Antibody

CAT: 0800-V8734-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8734-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells. B7-H6 binds with NKp30 present on NK cells. Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis. B7-H6 is not constitutively expressed on normal tissue. Whether it can be expressed endogenously under certain conditions is under investigation. B7-H6 has been detected on circulating pro-inflammatory CD14 (+) CD16 (+) monocytes in some patients with sepsis.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q68D85
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 38-169 from the human protein was used as the immunogen for the B7-H6 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
B7H6/4821
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the B7-H6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This B7-H6 antibody is available for research use only.
Storage Conditions
Store the B7-H6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the B7-H6 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human tonsil with B7-H6 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q68D85

Natural cytotoxicity triggering receptor 3 ligand 1

NR3L1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q68D85
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NCR3LG1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q7Z3M6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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