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TH023

CAT: 0804-HY-168207Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168207Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH023 is an inhibitor for the TLR4 signaling pathway, that targets especially the formation of TLR4 homodimer. TH023 inhibits secreted embryonic alkaline phosphatase in cell HEK-Blue hTLR4 with an IC50 of 0.354 μM, and inhibits the NO expression in RAW264.7 with an IC50 of 1.61μM. TH023 also inhibits the activation of NF-κB, reduces the nuclear translocation of NF-κB p65. TH023 exhibits anti-inflammatory efficacy in LPS -induced mouse acute sepsis model, and ameliorates the mouse lung injury[1].
UNSPSC
12352005
Target
NF-κB; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/th023.html
Smiles
O=C(C1=C2N=C(C3=CC=C(Cl)C=C3)C=C(C(F)F)N2N=C1)N4C[C@]5([H])CCCC[C@]5([H])C4
Molecular Formula
C22H21ClF2N4O
Molecular Weight
430.88
References & Citations
[1]Jiang YY, et al., Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4-TLR4∗ homodimerization via AI-powered next-generation screening. Eur J Med Chem. 2024 Oct 6;280:116945.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19240348-01TH023

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