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TH023

CAT: 0931-T201758-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201758-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Adrenergic Receptor, TLR, NF-κB
Related Pathways
Neuroscience, NF-κB, Immunology/Inflammation, GPCR/G Protein
Bioactivity
TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.
Molecular Formula
C22H21ClF2N4O
Molecular Weight
430.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19240348-01TH023

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